A 28 year old caucasian female has newly diagnosed hypertension. She has been in otherwise excellent health and is only on Zyrtec 10mg daily for seasonal allergies. She presents her prescription for Micardis 40mg daily. As the counseling pharmacist, which details would be appropriate to discuss with this patient upon picking up the prescription? Select all that apply.
A. Any abrupt facial/lip swelling should prompt the patient to discontinue the agent and call a healthcare provider immediately.
B. Tablets should be stored in an amber bottle away from extreme temperatures to prevent degradation.
C. Doses should be taken with food in order to maximize absorption.
D. Micardis should be discontinued if patient is found to be pregnant to limit potential adverse effects to the fetus.
E. Caution with salt substitutes is warranted as Micardis may increase potassium concentrations.
Answers with rationale.
The correct answers are A, D, and E. Answer A is essentially describing angioedema, which is a potential side effect of angiotensin receptor blockers. While not as common as in ACE-inhibitors, it would require immediate discontinuation as this is an absolute contraindication. Answer D is correct as ACE-I and ARBs have known teratogenic effects. For this reason, often in females of child bearing age diuretics or calcium channel blockers are often given instead of RAAS agents. Answer E is correct as written due to ARB effects on RAAS especially aldosterone. Aldosterone decreases leads to potassium increases. Answer B is incorrect as Micardis (or Micardis HCT) should be kept in foil package until just before administering due to potential of loss of potency. Answer C is incorrect as Micardis may be taken with or without food. Some medications like posaconzole suspension or Xarelto (treatment dosage of 20mg daily) require food for optimal absorption.
Have a great weekend as you head into the final home stretch before graduation!