Which of the following malignancies are patients with rheumatoid arthritis specifically at higher risk for?
A. Colon cancer
B. Lung cancer
E. Glioblastoma multiforme
The answer is C. (Chap. 380) Large cohort studies have shown a two- to fourfold increased risk of lymphoma in RA patients compared with the general population. The most common histopathologic type of lymphoma is a diffuse large B-cell lymphoma. The risk of developing lymphoma increases if the patient has high levels of disease activity or Felty syndrome.