Neuropathology of Parkinsonian Syndrome Diagnosis

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Macroscopic findings in PD. Transverse sections of the hemi-midbrain at the level of the third nerve in a patient with long-standing PD (A) and an elderly normal individual (B). The major difference is loss of neuromelanin pigment that is most marked in the ventrolateral parts of the substantia nigra (arrow).

Source: Watts RL, Standaert DG, Obeso JA. Movement Disorders, 3e; 2012

Leah Carton

Associate Editor - Pediatrics, Dermatology, Geriatrics , McGraw Hill