VII-22. All of the following are likely causes of glomerular damage leading to renal failure EXCEPT:
A. Diabetes mellitus
B. Fanconi syndrome
C. Lupus nephritis
D. Malignant hypertension
E. Mutation of TRPC6 cation channel
VII-22. The answer is B. (See Harrison’s 19e Chapter 338) There are a wide variety of diseases that can cause glomerular injury to the kidney, ranging from genetic conditions such as TRPC6 mutation causing cation channel dysfunction and associated focal segmental glomerulosclerosis to glomerular stress from systemic hypertension and/or diabetes mellitus. Inflammatory disease, such as lupus nephritis, Wegener granulomatosis, and poststreptococcal glomerulonephritis, may also cause glomerular disease. Fanconi syndrome is a classic disease of tubular dysfunction with associated aminoaciduria, type 2 renal tubular acidosis, and rickets, not glomerular disease.