The correct answer is 2 – Marfan’s syndrome. The effects of Marfan syndrome, inherited as an autosomal dominant trait, can be widespread and can affect many parts of the body, including the:

1. Skeletal system: long, slender limbs and fingers, as well as a tall and thin body type. They may also have a curved spine (scoliosis) and generalized hypermobility.
2. Cardiovascular system: Marfan syndrome can affect the heart and blood vessels and is the leading cause of aortic aneurysms and dissections.
3. Eyes: dislocated lenses, nearsightedness, or other eye problems.
4. Lungs: Some people with Marfan syndrome may have a collapsed lung (pneumothorax) or a breathing-related sleep disorder such as sleep apnea.

Ankylosing spondylitis (AS) is a type of chronic inflammatory arthritis that primarily affects the spine and the sacroiliac joints, causing inflammation in the joints and surrounding tissues, leading to pain, stiffness, and progressive loss of mobility in the spine.

Lyme disease is an infectious disease caused by the bacterium Borrelia burgdorferi, which is transmitted to humans through the bite of infected black-legged ticks (deer ticks). If left untreated by antibiotics, Lyme disease can cause serious symptoms such as joint pain and swelling and cardiac and neurologic problems.

Reiter syndrome, also known as reactive arthritis, is a type of arthritis that occurs after an infection with a sexually transmitted disease (such as Chlamydia or gonorrhea), a gastrointestinal infection (such as food poisoning), or a respiratory infection (such as a urinary tract infection).