Rank the following insulin products from longest duration of action to shortest duration of action.
C. U-500 insulin
Correct answer with rationale: The correct order is D-B-C-A. One of the 5 question types on the NAPLEX is ordered response, where you will have to rank a number of agents in some delineated pattern. The example given in the candidate's guide is potency of topical corticosteroids. Be careful to read the question carefully and not give the wrong order (i.e. in this question you accidentally "read" rank from shortest to longest). This is a potentially 6 hour exam and you will get tired so can easily happen! Insulin degludec (Tresiba) is a basal insulin with a very long duration of action and therefore would be first, followed by another basal insulin (insulin detemir or Levemir), U-500 which is a form of regular insulin, and finally Novolog which is a rapid acting, mealtime insulin.
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