JB is a 43 year old female is having multiple GI complaints and through eventual consultation with gastroenterology and workup is determined to have ulcerative colitis. Initial treatment options are being discussed with the gastroenterologist and frequency of administration is an important factor for her. She is a senior executive at her CPA practice and it is very difficult to leave her practice during the day especially during tax season.
Rank the following agents from least frequent maintenance dosing schedule to most frequent maintenance dosing schedule.
Answer with rationale:
The correct order is C-B-D-A. There are a number of immunomodulatory agents used currently in the management of IBD including ulcerative colitis. Infliximab (Remicade) is generally given intravenously q 8 weeks in the maintenance phase, which would be very helpful for our busy patient. Adalimumab (Humira) is dosed every other week in those patients who demonstrate a clinical response within 8 weeks of therapy initiation. Methotrexate is given once weekly either IM or PO while azathioprine is administered orally daily.
While the question focuses on frequency of administration, dosing forms will be an important part of the decision process for our patient as you have IM, SQ, PO, and IV options available. A discussion of all factors related to the patient's options will be prudent. Even though infliximab is only given q8 weeks, she may elect to try oral therapy which would not require her leaving the office as much.
Knowledge of dosage forms and administration schedules is crucial for the examination. This expertise by pharmacists helps to ensure the best regimen is given to our patients based on their individual needs.