Neurofibromatosis type I (Lisch nodule). Lisch nodules are melanocytic hamartomas occurring on the iris. They can be seen on routine examination of the eye, but a slit lamp is required to distinguish these lesions from nevi. Lisch nodules are brown and dome-shaped and measure up to 2 mm in diameter. The majority of patients with NF1 develop this finding during childhood, and the nodules are present in the vast majority of adolescents and adults with the disorder. The nodules do not cause any ophthalmologic complication.
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